The Buffalo Bills' defense has a lot to account for on "Monday Night Football."
Los Angeles Rams star receiver Puka Nacua can hurt them across the middle. Davante Adams can attack outside. And Kyren Williams has become a bigger part of the passing game, having posted 16 catches over the past two weeks, so Buffalo's linebackers have to handle the run and track Williams when he leaves the backfield. That can leave space behind them for Nacua.
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Buffalo needs James Cook III to make the Rams' defense respect the run. The Rams are allowing just 4.8 yards per pass attempt, so asking Josh Allen to carry everything through the air is a tough assignment. Cook can help draw the attention of defenders and open up play-action, while Allen's legs add another problem because coverage can hold up and he can still move the chains. If DJ Moore sits, Buffalo needs Keon Coleman to give Allen somewhere to go outside when the Rams crowd the middle.
Betting outlook
I would consider the Rams -3 because their scoring hasn't matched how well they've moved the ball. They're sixth in yards per play but average just 21.3 points per game. Turnovers explain part of that gap. Matthew Stafford already has six interceptions, after throwing eight all last season, and Los Angeles collectively has committed multiple turnovers in four straight games. I wouldn't assume that it suddenly disappears, but I also wouldn't treat this stretch as what we should expect every week.